Thioredoxin reductase drug resistance
WebAnalysis of thioredoxin reductase activity in the cell extracts of MV4-11 and MV4-11R cells showed that the enzyme activity was significantly increased in the sorafenib-resistant … WebAur R Lines Do Not Harbor Mutations in the Thioredoxin Reductase Gene. Considering that thioredoxin reductase (Sannella et al., 2008; Angelucci et al., 2009; Debnath et al., 2012; Ilari et al., 2012) is the proposed target of auranofin, we hypothesized that resistance in T. gondii would develop through mutations to the parasite thioredoxin reductase gene (TgTrxR, …
Thioredoxin reductase drug resistance
Did you know?
WebJan 2, 2024 · Glutathione (GSH)/GSH reductase (GSR) and thioredoxin (TXN)/thioredoxin reductase (TXNRD) are two parallel, compensating thiol-dependent antioxidant pathways that regulate and maintain cellular thiol redox homeostasis and protein dithiol/disulfide balance ().Both GSH and TXN catalyze the reduction of disulfide bonds in proteins to … WebAlthough the covalent inhibition of thioredoxin reductase (TrxR), an enzyme that critically controls intracellular redox homeostasis, is considered the primary mechanism of AF’s …
WebJun 1, 2024 · Thioredoxin Reductase (TrxR) plays a pivotal role in defending cells against reactive oxygen species (ROS) and maintaining a reduced intracellular environment. ... and enhancing tumor drug resistance. Also, it has been reported that its levels are elevated significantly in several human cancers, ... WebThioredoxin Reductase (TrxR) plays a pivotal role in defending cells against reactive oxygen species (ROS) and maintaining a reduced intracellular environment. It has been …
WebMar 3, 2016 · Thioredoxin reductase is not the sole target for ... M. N. Antibacterial activity of novel cationic peptides against clinical isolates of multi-drug resistant Staphylococcus pseudintermedius from ... WebThioredoxin reductase (TrxR) from the Gram-positive bacterial antioxidant thioredoxin system has emerged from multiple screening efforts as a potential target for auranofin, …
WebNov 21, 2024 · Request PDF A Derivative of Piperlongumine and Ligustrazine as a Potential Thioredoxin Reductase Inhibitor in Drug-Resistant Hepatocellular Carcinoma The natural products piperlongumine (1 ...
WebJun 19, 2007 · Because praziquantel resistance may develop it is essential to identify novel drug targets. Our goal was to investigate the potential of a unique, selenium-containing parasite enzyme thioredoxin glutathione reductase (TGR) as a drug target. boba athensWebThe improvement of Chagas disease treatment is focused not only on the development of new drugs but also in understanding mechanisms of action and resistance to drugs conventionally used. Thus, some strategies aim to detect specific changes in boba babe twitterWebThioredoxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest. Invest New Drugs. 2011 Aug;29(4):627-36. … boba at sonic drive inWebApr 1, 2024 · Thioredoxin reductases (TrxR) was reported to be overexpressed in most tumors and closely related to high risk of cancer recurrence and drug resistance, making it a potential target for anticancer ... boba at home kitsWebMar 25, 2024 · Radiotherapy is an effective treatment modality for breast cancer but, unfortunately, not all patients respond fully with a significant number experiencing local recurrences. Overexpression of thioredoxin and thioredoxin reductase has been reported to cause multidrug and radiation resistance - their inhibition may therefore improve … boba at the landingWebFeb 28, 2024 · Both complexes 19 and 20 can decrease the total thiols in both cisplatin-resistant and -sensitive cell lines, with cisplatin influencing the thiol concentration to a lower extent and only in the sensitive cell line. In addition, another mechanism of cytotoxicity is related to its influence on thioredoxin reductase (TrxR) activity. climbing barefootWebThe collective perspective is that TrxR can be targeted through new drug development with the aim of impacting predominately Gram-positive and glutathione independent bacteria. Thioredoxin System The TS is present in all living cells, inclusive of bacteria and fungi. climbing baffin island