TfR1 is a transmembrane glycoprotein composed of two disulfide-linked monomers joined by two disulfide bonds. Each monomer binds one holo-transferrin molecule creating an iron-Tf-TfR complex which enters the cell by endocytosis. See more Transferrin receptor protein 1 (TfR1), also known as Cluster of Differentiation 71 (CD71), is a protein that in humans is encoded by the TFRC gene. TfR1 is required for iron import from transferrin into cells by See more TfR1 as a potential new target in cases of human leukemia & lymphoma. InatherYs, in Évry, France, developed a candidate drug, INA01 antibody (anti-CD71) that showed efficacy in … See more • Transferrin receptor 2 • Cluster of differentiation See more TfR1 has been shown to interact with GABARAP and HFE. See more CD71 is a robust immunohistochemistry marker for chorionic villi, especially in necrotic specimens. Among white blood cells and precursors, … See more • Overview of all the structural information available in the PDB for UniProt: P02786 (Human Transferrin receptor protein 1) at the PDBe-KB. See more WebImportantly, the overexpressed membrane receptors on the brain endothelial cells, especially transferrin receptor 1 (TfR1), which mediate their ligands/antibodies to overcome the BBB by transcytosis, have been emerging as promising targets for brain tumor therapy.
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Web27 May 2024 · In this study, we used ⁸⁹Zr-immuno-PET to evaluate the targeting and distribution of a bispecific brain-shuttle IgG based on Adu with transferrin receptor protein … WebTransferrin receptor (TfR) mediated brain uptake and peripheral clearance of erythropoietin (EPO) fused to a monoclonal antibody against the TfR (TfRMAb). TfRMAb-EPO binds to … jd dana minerology book
Brain delivery of therapeutic proteins using an Fc fragment blood …
Web20 Sep 2024 · Given that the expression of TfR1 was also significantly upregulated in the brain in stressed mice, our findings together with previous studies provide an interesting … WebA synthetic phage display library based on the variable domain of new antigen receptor (VNAR) was used for in vitro selection against recombinant human TfR1 ectodomain (rh … Web27 May 2024 · Denali researchers tested out the transporter using an antibody targeting β-secretase 1, an enzyme implicated in amyloid build-up in the brains of people with … jd dani mor uhr